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8.2 Lactation, risk summary. Cyclosporine is known to appear in human milk following systemic administration, but its presence in human milk following topical treatment has not been investigated. Although blood concentrations are undetectable following topical administration of Restasis ophthalmic emulsion see clinical Pharmacology (.3 caution should be exercised when Restasis is administered to a nursing woman. The developmental and health benefits of breastfeeding should be considered along with the mothers clinical need for Restasis and any potential adverse effects on the breast-fed child from cyclosporine. 8.4 Pediatric Use. Safety and efficacy have not been established in pediatric patients below the age. 8.5 Geriatric Use no overall difference in safety or effectiveness has been observed between elderly and younger patients.
Reported reactions have included: hypersensitivity (including eye swelling, urticaria, rare cases of severe angioedema, face swelling, tongue swelling, pharyngeal edema, and dyspnea and superficial injury of the eye (from the vial tip touching the eye during administration). 8 use IN specific populations.1 Pregnancy, risk summary. Clinical administration of cyclosporine ophthalmic emulsion.05 is not detected systemically following topical ocular administration see clinical Pharmacology (.3 and maternal use is not expected to result in fetal exposure to the drug. Oral administration of cyclosporine to pregnant rats or rabbits did not produce teratogenicity at clinically relevant doses see Data. Data, animal Data, at maternally toxic doses (30 mg/kg/day aloe in rats and 100 mg/kg/day in rabbits cyclosporine oral solution (USP) was teratogenic as indicated by increased pre- and postnatal mortality, reduced fetal weight and skeletal retardations.
These doses (normalized to body surface area) are 5,000 and 32,000 times greater, respectively, than gember the daily recommended human dose of one drop (approximately 28 mcL) of cyclosporine ophthalmic emulsion.05 twice daily into each eye of a 60 kg person (0.001 mg/kg/day assuming that. No evidence of embryofetal toxicity was observed in rats or rabbits receiving cyclosporine during organogenesis at oral doses up to 17 mg/kg/day or 30 mg/kg/day, respectively. These doses in rats and rabbits are approximately 3,000 and 10,000 times greater, respectively, than the daily recommended human dose. An oral dose of 45 mg/kg/day cyclosporine administered to rats from day 15 of pregnancy until day 21 postpartum produced maternal toxicity and an increase in postnatal mortality in offspring. This dose is 7,000 times greater than the daily recommended human dose. No adverse effects in dams or offspring were observed at oral doses up to 15 mg/kg/day (2,000 times greater than the daily recommended human dose).
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Lenses may be reinserted 15 minutes following serum administration of Restasis ophthalmic emulsion. 6 adverse reactions, the following serious adverse reactions are described elsewhere in the labeling: Potential for eye injury and Contamination see warnings and Precautions (.1 ).1 Clinical Trials Experience. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In clinical trials, the most common adverse reaction following the use of Restasis was ocular burning (17). Other reactions reported in 1 to 5 of patients included conjunctival hyperemia, discharge, epiphora, eye pain, foreign body sensation, pruritus, stinging, and visual disturbance (most often blurring). 6.2 Post-marketing Experience, the following adverse reactions have been identified during post approval use of Restasis. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
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3 dosage forms and strengths. Ophthalmic emulsion containing cyclosporine.5 mg/mL 4 contraindications, restasis is contraindicated in patients with known or suspected hypersensitivity to any of lauder the ingredients in the formulation. 5 warnings and precautions.1 Potential for eye injury and Contamination. Be careful not to touch the vial tip to your eye or other surfaces to avoid potential for eye injury and contamination. 5.2 Use with Contact Lenses, restasis should not be administered while wearing contact lenses. Patients with decreased tear production typically should not wear contact lenses. If contact lenses are worn, they should be removed prior to the administration of the emulsion.
Generic Name: cyclosporine, dosage form: ophthalmic emulsion, medically reviewed on July 1, 2017, show On This Page. View All 1 indications and usage, restasis ophthalmic emulsion is indicated to increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca. Increased tear production was not seen in patients currently taking topical anti-inflammatory drugs or using punctal plugs. 2 dosage AND administration, invert the unit dose vial a few times to obtain a uniform, white, kosten opaque emulsion before using. Instill one drop of Restasis ophthalmic emulsion twice a day in each eye approximately 12 hours apart. Restasis can be used concomitantly with lubricant eye drops, allowing a 15-minute interval between products. . Discard vial immediately after use.
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